Pesquisa sobre:
SUPPRESSOR OF CYTOKINE SIGNALING 3 PROTEIN
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DeCS
Descritor
Inglês
:
Suppressor of Cytokine Signaling 3 Protein
Descritor
Espanhol
:
Proteína 3 Supresora de la Señalización de Citocinas
Descritor
Português
:
Proteína 3 Supressora da Sinalização de Citocinas
Sinônimos
Inglês
:
SOCS3 Protein
Suppressor of Cytokine Signaling Protein 3
Protein, SOCS3
Categoria:
D12.644.360.024.374.750
D12.776.157.057.249.750
D12.776.476.024.437.750
Definição
Inglês
:
A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3
UBIQUITIN-PROTEIN LIGASE COMPLEXES
). SOCS3 inhibits cytokine signaling by binding to
RECEPTOR PROTEIN-TYROSINE KINASES
as well as
CYTOKINE RECEPTOR GP130
;
ERYTHROPOIETIN
RECEPTORS;
INSULIN
RECEPTOR; and the
LEPTIN
RECEPTOR. Its functions include
suppression
of
ERYTHROPOIESIS
in the fetal liver.
Nota Histórica
Inglês
:
2017
Qualificadores Permitidos
Inglês
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número do Registro:
56544
Identificador Único:
D000071223
Ocorrência na BVS
:
Similar:
DeCS
CID-10
SciELO
LILACS
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